Publications of the Hyman Group

Guillén-Boixet, J.; Kopach, A.; Holehouse, A. S.; Wittmann, S.; Jahnel, M.; Schlüßler, R.; Kim, K.; Trussina, I. R.E.A.; Wang, J.; Mateju, D. et al.; Poser, I.; Maharana, S.; Ruer-Gruß, M.; Richter, D.; Zhang, X.; Chang, Y.-T.; Guck, J.; Honigmann, A.; Mahamid, J.; Hyman, A. A.; Pappu, R. V.; Alberti, S.; Franzmann, T. M.: RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation. Cell 181 (2), pp. 346 - 361 (2020)

Iserman, C.; Desroches Altamirano, C.; Jegers, C.; Friedrich, U.; Zarin, T.; Fritsch, A. W.; Mittasch, M.; Domingues, A.; Hersemann, L.; Jahnel, M. et al.; Richter, D.; Guenther, U.-P.; Hentze, M. W.; Moses, A. M.; Hyman, A. A.; Kramer, G.; Kreysing, M.; Franzmann, T. M.; Alberti, S.: Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production. Cell (2020)

Nüske, E.; Marini, G.; Richter, D.; Leng, W.; Bogdanova, A.; Franzmann, T. M.; Pigino, G.; Alberti, S.: Filament formation by the translation factor eIF2B regulates protein synthesis in starved cells. Biology Open 9, bio046391 (2020)

Ivanov, I.; Lira, R. d.; Tang, T.-Y. D.; Franzmann, T.; Klosin, A.; Caire da Silva, L.; Hyman, A.; Landfester, K.; Lipowsky, R.; Sundmacher, K. et al.; Dimova, R.: Directed Growth of Biomimetic Microcompartments. Advanced Biosystems 3 (6), 1800314 (2019)

Enos, S. J.; Dressler, M.; Ferreira Gomes, B.; Hyman, A. A.; Woodruff, J. B.: Phosphatase PP2A and microtubule-mediated pulling forces disassemble centrosomes during mitotic exit. Biology Open 7 (1), bio029777 (2018)

Franzmann, T. M.; Jahnel, M.; Pozniakovsky, A.; Mahamid, J.; Holehouse, A. S.; Nüske , E.; Richter, D.; Baumeister, W.; Grill, S. W.; Pappu, R. V. et al.; Hyman, A. A.; Alberti, S.: Phase separation of a yeast prion protein promotes cellular fitness. Science 359 (6371), eaao5654 (2018)

Jawerth, L.; Ijavi, M.; Ruer, M.; Saha, S.; Jahnel, M.; Hyman, A. A.; Jülicher, F.; Fischer-Friedrich, E.: Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical Traps. Physical review letters 121 (25), 258101 (2018)

Maharana, S.; Wang, J.; Papadopoulos, D.; Richter, D.; Pozniakovsky, A. I.; Poser, I.; Bickle, M.; Rizk, S.; Guillén-Boixet, J.; Franzmann, T. et al.; Jahnel, M.; Marrone, L.; Chang, Y.-T.; Sterneckert, J.; Tomancak, P.; Hyman, A.; Alberti, S.: RNA buffers the phase separation behavior of prion-like RNA binding proteins. Science (New York, N.Y.) 360 (6391), pp. 918 - 921 (2018)

Schwille, P.; Spatz, J.; Landfester, K.; Bodenschatz, E.; Herminghaus, S.; Sourjik, V.; Erb, T.; Bastiaens, P.; Lipowsky, R.; Hyman, A. et al.; Dabrock, P.; Baret, J. P.; Vidaković-Koch, T.; Bieling, P.; Dimova, R.; Mutschler, H.; Robinson, T.; Tang, D.; Wegner, S.; Sundmacher, K.: MaxSynBio - Avenues towards creating cells from the bottom up. Angewandte Chemie International Edition 57 (41), pp. 13382 - 13392 (2018)

Schwille, P.; Spatz, J. P.; Landfester, K.; Bodenschatz, E.; Herminghaus, S.; Sourjik, V.; Erb , T.; Bastiaens, P.; Lipowsky, R.; Hyman, A. A. et al.; Dabrock, P.; Baret, J.-C.; Vidaković-Koch, T.; Bieling, P.; Dimova, R.; Mutschler , H.; Robinson, T.; Tang, T.-Y. D.; Wegner, S.; Sundmacher, K.: MaxSynBio: Wege zur Synthese einer Zelle aus nicht lebenden Komponenten. Angewandte Chemie 130 (41), pp. 13566 - 13577 (2018)

Wang, J.; Choi, J.-M.; Holehouse, A. S.; Lee, H. O.; Zhang, X.; Jahnel, M.; Maharana, S.; Lemaitre, R. P.; Pozniakowski, A.; Drechsel, D. et al.; Poser, I.; Pappu, R. V.; Alberti, S.; Hyman, A. A.: A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins. Cell 174 (3), pp. 688 - 699 (2018)

Kroschwald, S.; Alberti, S.: Gel or Die: Phase Separation as a Survival Strategy. Cell 168 (6), pp. 947 - 948 (2017)

Mateju, D.; Franzmann, T. M.; Patel, A.; Kopach, A.; Boczek, E. E.; Maharana, S.; Lee, H. O.; Carra, S.; Hyman, A. A.; Alberti, S.: An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function. The EMBO Journal 36, pp. 1669 - 1687 (2017)

Woodruff, J. B.; Ferreira Gomes, B.; Widlund, P. O.; Mahamid, J.; Honigmann, A.; Hyman, A. A.: The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin. Cell 169 (6), pp. 1066 - 1077 (2017)

Woodruff, J. B.; Hyman, A. A.; Boke, E.: Organization and Function of Non-dynamic Biomolecular Condensates. Trends in Biochemical Sciences 43 (2), pp. 81 - 94 (2017)

Boke, E.; Ruer, M.; Wühr, M.; Coughlin, M.; Lemaitre, R.; Gygi, S. P.; Alberti, S.; Drechsel, D.; Hyman, A.; Mitchison, T. J.: Amyloid-like Self-Assembly of a Cellular Compartment. Cell 166 (3), pp. 637 - 650 (2016)

Saha, S.; Weber, C. A.; Nousch, M.; Adame-Arana, O.; Hoege, C.; Hein, M. Y.; Osborne-Nishimura, E.; Mahamid, J.; Jahnel, M.; Jawerth, L. et al.; Pozniakovski, A.; Eckmann, C. R.; Jülicher, F.; Hyman, A. A.: Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism. Cell 166 (6), pp. 1572 - 1584 (2016)

Wueseke, O.; Zwicker, D.; Schwager, A.; Wong, Y. L.; Oegema, K.; Jülicher, F.; Hyman, A.; Woodruff, J. B.: Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation. Biology Open 5, pp. 1431 - 1440 (2016)

Zwicker, D.; Seyboldt, R.; Weber, C. A.; Hyman, A. A.; Jülicher, F.: Growth and division of active droplets provides a model for protocells. Nature Physics 13 (4), pp. 408 - 413 (2016)

Patel, A.; Lee, H. O.; Jawerth, L.; Maharana, S.; Jahnel, M.; Hein, M. Y.; Stoynov, S.; Mahamid, J.; Saha, S.; Franzmann, T. M. et al.; Pozniakovski, A.; Poser, I.; Maghelli, N.; Royer, L. A.; Weigert, M.; Myers, E. W.; Grill, S.; Drechsel, D.; Hyman, A. A.; Alberti, S.: A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation. Cell 162 (5), pp. 1066 - 1077 (2015)