![#19 - Identifying causal mutations that impact cell growth to “de-bug” yeast synthetic chromosomes #19 - Identifying causal mutations that impact cell growth to “de-bug” yeast synthetic chromosomes](/3568791/header_image-1606427144.jpg?t=eyJ3aWR0aCI6ODQ4LCJmaWxlX2V4dGVuc2lvbiI6ImpwZyIsIm9ial9pZCI6MzU2ODc5MX0%3D--dd1a3227050c201935e52a7e9f9c2241aab9755a)
#19 - Identifying causal mutations that impact cell growth to “de-bug” yeast synthetic chromosomes
Bryan Leland (Inscripta)
Monday, 30 Nov and Tuesday, 01 Dec 21:15 - 22:00 CET
Access to the BigBlueButton rooom for this Mini Talk via the lists for Monday and Tuesday.
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Abstract
Title: Identifying causal mutations that impact cell growth to “de-bug” yeast synthetic chromosomes
Author(s): Bryan Lelanda, Leslie Mitchellb, Richard Foxa, Katherine Krousea, Jef Boekeb and Nandini Krishnamurthya
Affiliation(s): aInscripta, Boulder; bNYU Langone Medical Center, New York
Abstract: Understanding how biology works requires powerful tools for manipulating genomes. Inscripta’s Onyx™ platform enables precise, high-throughput engineering of microbial genomes, offering an end-to-end solution from library design through automated strain engineering and analytics, including software, reagents, and a benchtop instrument. This helps to target diverse edits across the genome and unlock genotype-phenotype relationships at an unprecedented scale. we will discuss our work using the Onyx platform to perform genome-wide engineering of S. cerevisiae for strain optimization and “de-bugging” of yeast synthetic chromosomes.