#19 - Identifying causal mutations that impact cell growth to “de-bug” yeast synthetic chromosomes
Bryan Leland (Inscripta)
Monday, 30 Nov and Tuesday, 01 Dec 21:15 - 22:00 CET
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Title: Identifying causal mutations that impact cell growth to “de-bug” yeast synthetic chromosomes
Author(s): Bryan Lelanda, Leslie Mitchellb, Richard Foxa, Katherine Krousea, Jef Boekeb and Nandini Krishnamurthya
Affiliation(s): aInscripta, Boulder; bNYU Langone Medical Center, New York
Abstract: Understanding how biology works requires powerful tools for manipulating genomes. Inscripta’s Onyx™ platform enables precise, high-throughput engineering of microbial genomes, offering an end-to-end solution from library design through automated strain engineering and analytics, including software, reagents, and a benchtop instrument. This helps to target diverse edits across the genome and unlock genotype-phenotype relationships at an unprecedented scale. we will discuss our work using the Onyx platform to perform genome-wide engineering of S. cerevisiae for strain optimization and “de-bugging” of yeast synthetic chromosomes.